WUXI AIRDRILLING TECHNOLOGY CO., LTD
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About Us
Wuxi AirDrilling Technology Co., Ltd. is a China AirDrilling Technology, manufacturer located in Wuxi, Jiangsu Province. We are a professional manufacturer engaged in the development, research and production of drilling rig air tools.A purine nucleoside derivative, phosphonoformic acid, enhances the antiviral activity of the nucleoside analogs adefovir and tenofovir against hepatitis B virus.
Recent studies have shown that phosphonoformic acid (PFA) induces the redistribution of the transcription factor, Sp1, into the nucleus in adefovir (ADV)- or tenofovir (TDF)-treated hepatoma cells. The aim of this study was to determine whether the combination of PFA and nucleoside analogs (NA) enhances the in vitro activity of NA against hepatitis B virus (HBV). Infectious DNA copies of the HBV genotype D lamivudine (LAM)-resistant (L180M) mutant were introduced into HepG2 cells. The cells were treated with combination of LAM and PFA or ADV/TDF for 7 days. The numbers of the intracellular HBV DNA copies were determined by real-time polymerase chain reaction. The viral replication was significantly reduced by the combination of LAM and PFA or ADV/TDF. However, the reduction effect of PFA was significant only in cells treated with 10 μM PFA. Treatment with PFA for 7 days induced the redistribution of Sp1 into the nucleus in LAM-treated cells. PFA treatment reduced the levels of the HBV envelope protein and the intracellular HBV DNA copies in TDF-treated cells, but only slightly in ADV-treated cells. Therefore, we demonstrated that the combination of NA and PFA enhances the antiviral activity of NA against HBV.Q:
How do you restore default state after a work package is opened
I opened a work package and I'm not sure how to restore the state it was in before I opened it.
A:
Unfortunately, I have not found a way to automatically restore the states. However, you can save your states to a copy (my practice is to call them backups) and load those back in if need be.
Or you can import the actions and states you make into any other be359ba680
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